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Cosmetics Ingredients
The material selection platform
Cosmetics Ingredients


CAS Number 616204-22-9
Chem/IUPAC Name: Acetyl hexapeptide-8 is the synthetic peptide consisting of arginine, methionine, and acetylated glutamic acid residues
COSING REF No: 54135
Acetyl Hexapeptide-8, commonly known as Argireline, is a peptide used in cosmetics for its potential anti-aging effects. It is a synthetic peptide made up of six amino acids. Acetyl Hexapeptide-8 is believed to work by reducing the appearance of fine lines and wrinkles caused by facial expressions. It is often found in skincare products, particularly those targeting the signs of aging. In terms of appearance, Acetyl Hexapeptide-8 is typically a white, crystalline powder. Consumers can find a range of skincare products formulated with Acetyl Hexapeptide-8, such as serums, creams, and anti-aging treatments. The chemical formula of Acetyl Hexapeptide-8 is C34H60N14O12S.

What is ACETYL HEXAPEPTIDE-8 used for?

Acetyl Hexapeptide-8 is used widely in cosmetics and personal care products for its potential anti-aging properties. It is primarily employed as a topical alternative to Botox, aiming to reduce the appearance of fine lines and wrinkles caused by facial muscle contractions. Acetyl Hexapeptide-8 works by inhibiting the release of neurotransmitters that stimulate muscle contractions, resulting in a temporary relaxation of facial muscles. This peptide is often incorporated into skincare formulations, including serums and creams, targeting specific areas prone to wrinkles, such as the forehead, crow's feet, and frown lines.


Acetyl Hexapeptide-8 is produced through synthetic methods using solid-phase peptide synthesis. The process involves sequentially coupling and activating the amino acids to form the hexapeptide chain. Acetyl groups are added to the N-terminus of the peptide to enhance stability and efficacy.

What does ACETYL HEXAPEPTIDE-8 do in a formulation?

  • Humectant
  • Skin conditioning

Safety profile

Acetyl Hexapeptide-8 is a non-toxic ingredient and is safe for the skin. It is also not known to be comedogenic, meaning it does not cause acne and breakouts. Nevertheless, patch testing should be done before using any product containing Acetyl Hexapeptide-8. Lastly, being synthetically derived, this ingredient is vegan and does not have any animal based components.


Technical profile

Property Values
pH 6.0-7.0
Solubility Soluble in water
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