TAGS: Skin Care
Sabinsa publishes first human clinical study on anti-acne benefits of LactoSporin®, the probiotic metabolite derived from the highly regarded probiotic LactoSpore®. A second published study, in vitro, demonstrated the anti-aging potential of this topical ingredient. Together, the research supports the use of LactoSporin® for skin care applications.
Studies Anti-acne Effects of LactoSporin®
The study was conducted on 64 human volunteers with mild to moderate acne. As one of the first systematic clinical studies of a probiotic metabolite, the research demonstrates the efficacy of LactoSporin 2 percent w/w cream in reducing the severity of acne in human volunteers, with the effects comparable to benzoyl peroxide 2.5 percent gel.
The anti-acne effects of LactoSporin® were observed as early as three days. The three-week study measured improvement in skin condition based on dermatologist visual assessment and instrumental measurements of acne spots. A significant improvement in all the assessed parameters was observed in both LactoSporin® and benzyl peroxide groups.
Results: Reduction in Oiliness & Pimples
In addition, a significant decrease in sebaceous secretion was observed for LactoSporin®, which resulted in reduced oiliness, pimples, acne spots and redness around the acne spot. Further, LactoSporin® was found to be stable at an acidic pH and temperature range of 70 to 90°C, with antimicrobial activity against various pathogenic bacteria, including Cutibacterium acnes.
The study concluded that the efficacy of LactoSporin® was equivalent to benzoyl peroxide in the treatment of mild-to-moderate acne lesions and has an advantage over benzoyl peroxide in individuals with oily skin.
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LactoSporin®, a metabolic byproduct of our probiotic, to help improve the composition of the skin’s beneficial bacteria. This study clearly shows that LactoSporin is highly suitable for treating subjects with mild-to-moderate acne vulgaris,” commented Shaheen Majeed, president Worldwide of Sabinsa and a co-author of the study.
The cream was found to be safe and non-irritant in a repeated patch test conducted in 25 healthy individuals, prior to the anti-acne study.
LactoSporin® Prevents Moisture Loss from Skin
In the second study, LactoSporin® was evaluated for its role in preserving skin integrity in cultured cells in vitro. LactoSporin® was found to be a powerful
antioxidant with reactive oxygen quenching activity. The ingredient showed protection against UV-induced cellular damage and inhibited collagenase activity, suggesting its potential use in preventing accelerated aging.
LactoSporin® was also found to inhibit the activity of the enzyme hyaluronidase, thereby preventing hyaluronic acid fragmentation, the major cause of skin moisture loss. The results suggest that LactoSporin® could
keep the skin moisturized and maintain skin firmness. The study concluded that LactoSporin® is a skin protective postbiotic with wide application in cosmetic formulations.
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LactoSporin’s non-living microbial cell products possess several advantages over the probiotic itself, especially in skin care. It shows biological activity in a non-viable state, are easy to formulate, have favorable physiochemical properties and show improved inflammatory defense,” said Majeed.
Source: Sabinsa