TAGS: Skin Care
Shiseido has established a unique technology that visualizes nerve fibers in the skin in three dimensions to a depth of about two millimeters including the deep dermis layer and revealed that peripheral nerve fibers decrease with age, and the components released from sensory neurons stimulate the production of collagen in fibroblasts, which are involved in skin elasticity.
Shiseido Findings to Develop Skin Care Products
The research team also found that the Labiatae plant-derived component Phytoconnect has the effect of activating sensory neurons and increasing collagen production. This study suggests the possibility of a new skin care regimen that can create firm skin by caring for the nerves and going forward, Shiseido will apply this finding to the development of skin care products.
3D Visualization of Nerve Fibers
Shiseido has been engaged in research to study the relationship between nerves and skin especially the epidermis. However, the conventional methods were limited in terms of observable area and accuracy, and it was not possible to fully understand the complex network structure of nerves deep inside the skin.
Therefore, the team applied a unique technology that visualizes capillaries in the skin in three dimensions with a wide field of view using the method developed by Shiseido in 2018 that makes skin tissue transparent, and successfully achieved 3D visualization of nerve fibers deep inside the skin including the deep dermis layer for the first time (patent applied).
Using this technology, the team clearly observed a wider area up to a depth of about 2 millimeters and found that peripheral nerve fibers in the skin decrease with age and density decreases significantly. Based on these results, the team carried out research assuming that if there was a relationship between nerves and skin elasticity.
Role of Nerves in Human Skin
Shiseido has conducted research using human iPS-derived sensory neurons to elucidate the role of nerves in human skin. As a result of the study on the involvement of various cells in human skin, it was found that components released from human iPS-derived sensory neurons stimulate collagen production in fibroblasts, which are one of the cells that make up the dermis.
Phytoconnect Activates Sensory Neurons
The team explored ingredients that activate sensory neurons with a focus on the phenomenon that when sensory neurons are activated, the amount of released components increases. As a result, it was found that the Labiatae plant-derived ingredient Phytoconnect activates sensory neurons by simultaneously acting on three types of TRP channels (TRPA1, TRPM8, TRPV1) expressed in sensory nerves, and revealed that the collagen production in fibroblasts is further increased by the components released from these activated human iPS-derived sensory neurons.
Source: Shiseido