TAGS: Skin Care
Shiseido discovers that a skewing of balance between two types of macrophages (M1 and M2) is involved in the occurrence of “inflammaging”, which is an aging accelerated by chronic inflammation. The researchers have identified the possibility of a completely new anti-aging solution with a focus on inflammaging as a new approach to curb chronic skin inflammation and promote cell rejuvenation.
Elucidated the Mechanism of Inflammaging
Shiseido has already accumulated various knowledge through research on lymphatic vessels that are responsible for removing waste products. This time, in pursuit of normalization of the function to stop inflammation, the researchers conducted research to elucidate the mechanism of inflammaging by focusing on the balance between M1 and M2 macrophages.
It was well known that the balance between M1 and M2 macrophages (M1 / M2 balance) plays an important role in the process of healing wounds in the skin, however, little was known about its relationship with aging.
The scientists visualized macrophages in terms of the relationship of M1 / M2 balance with regard to skin aging in sun-exposed areas via immunohistochemical staining, and found that the population of M1 macrophages increased and M2 macrophages decreased in the mature group (average age of 73.5 years) compared to the younger group (average age of 33.5 years), and that the ratio of M1 macrophages was extremely high in the mature group.
New Approach to Anti-aging Skincare Solutions
Next, the researchers evaluated the effects of M1 and M2 macrophages on cellular senescence through experiments using dermal fibroblast culture. As a result, they discovered for the first time that the proportion of senescent cells (p21-positive cells) in fibroblasts significantly increased when a culture supernatant of M1 macrophages was applied.
Until now, anti-inflammatory solutions, which suppress inflammation intensity against inflammatory reactions caused by external stimuli, such as UV rays and dryness, have been the mainstream. However, for chronic inflammation that accelerates skin aging (inflammaging), it is necessary to create anti-inflammatory solutions that not only suppress inflammation intensity but also promote inflammation resolution.
In this study, the researchers revealed for the first time in the world that the skewing of M1 / M2 balance in the skin results in failure to alleviate chronic inflammation and causes inflammaging. This discovery can be expected to help develop a brand-new approach to anti-aging skincare solutions focused on inflammaging.
Shiseido will continue to develop
anti-aging skincare products that exceed consumer expectations for treatments of various skin problems.
Source: Shiseido