TAGS: Sustainability / Natural Cosmetics Skin Care
Shiseido has succeeded in reproducing a “thinning” phenomenon, which is characterized by a decreased thickness of the dermis caused by aging, using a three-dimensional (3D) skin model by leveraging the know-how for cell experiments gained from regenerative medicine research.
Related read: Better Aging vs. Anti-Aging
Development of Ingredients that Prevents Thinning of the Dermis
In the search for ingredients that prevent the thinning of the dermis, the company's original mixture of extracts consisting of Lonicera japonica flower extract, safflower extract, and Bupleurum root extract was found to have some effects.
The extract mixture will be applied to skin care products. Shiseido will continue to provide solutions to address aging concerns that many customers have, such as wrinkles and sagging.
The results of this study were orally presented in part at the 94th Annual Meeting of the Japanese Tissue Culture Association (July 7-8, 2022).
The development of methods to prevent or
improve wrinkles and sagging, which are
typical signs of aging, has long been desired as they represent major concerns related to aging. In response to such customer concerns, Shiseido has been engaged in research on skin aging for many years and has yielded ample knowledge, including the association between dermal stem cells and sagging and the mechanism by which immune cells eliminate senescent cells in the skin.
Skin Structure in Detail and Elucidates the Precise Mechanism
Thinning of the dermis is a phenomenon observed with aging, and it causes a loss of elasticity and weakening of the entire skin, leading to the formation of wrinkles and sagging. This time, Shiseido took on a challenge to develop a 3D skin model that reproduces the thinning of the dermis caused by aging in order to capture changes in the skin structure in detail and elucidate the precise mechanism underlying this phenomenon.
In the present study, Shiseido used its original dermal senescent cell model, which was developed with technologies the company has cultivated over years of regenerative medicine research and has made it possible to reproduce the characteristics of senescent cells such as overgrown cell size, cessation of cell proliferation, and detection of senescence markers, to develop a 3D skin model. The developed 3D skin model allowed for observation of age-related changes in the structure of the dermis, termed “thinning of the dermis,” which had been difficult to reproduce until now.
Thinning of the dermis is known to occur as a result of progressing decomposition of the extracellular matrix, which is composed of components such as collagen and elastin. Using the developed 3D skin model, it searched for ingredients that have the effect of improving the thinning of the dermis and discovered that their original extract mixture consisting of Lonicera japonica flower extract, safflower extract, and Bupleurum root extract had an effect to prevent the thinning of the dermis in the 3D skin model.
In addition, as it investigated further the effect of the original extract mixture to improve the thinning of the dermis, found that it had a suppressive effect on the gene expression of MMP1 (matrix metalloproteinase 1), a type of extracellular matrix-degrading enzymes.
The results of this study demonstrate that it is now possible to observe changes in the structure of the dermis associated with aging, i.e., the thinning of the dermis, which has been difficult to study in detail. It also achieved the identification of ingredients that can prevent this phenomenon. By applying these results, it will provide solutions to address aging signs that many of their customers are concerned about, such as wrinkles and sagging, beyond their expectations.
Source: Shiseido
