Researchers at the Keck School of Medicine of USC conducted one of the first longitudinal studies of PFAS and bone mineral density focused on young people of Hispanic origin.
A growing body of research has also linked the chemicals to lower bone mineral density, which can lead to osteoporosis and other bone diseases. But most of those studies have focused on older, non-Hispanic white participants and only collected data at a single point in time. They have replicated those results in a longitudinal study of two groups of young participants, primarily Hispanics, a group that faces a heightened risk of bone disease in adulthood.
Linked to Lower Baseline Bone Density in Young Adults
Per- and polyfluoroalkyl substances (PFAS), manufactured chemicals used in products such as food packaging and cosmetics, can lead to reproductive problems, increased cancer risk and other health issues.
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This is a population completely understudied in this area of research, despite having an increased risk for bone disease and osteoporosis,” said Vaia Lida Chatzi, MD, PhD, a professor of population and public health sciences at the Keck School of Medicine and the study’s senior author.
In a group of 304 adolescents, exposure to PFAS was linked to a decrease in bone mineral density over time. In a group of 137 young adults, PFAS exposure was also linked to lower baseline bone density, but no differences were observed over time.
PFAS are ubiquitous—we are all exposed to them. We need to eliminate that exposure to allow our youth to reach their full potential in terms of bone development to help them avoid osteoporosis later in life.
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Many existing studies haven’t included participants this young, but we’re now able to see that this association is already happening at a time when bones are supposed to be developing,” said Emily Beglarian, MPH, a doctoral student in the Keck School of Medicine’s Department of Population and Public Health Sciences and lead author of the study.
Need to Eliminate Exposure to PFAS
The researchers say the findings highlight the need for stricter regulation of PFAS, which have contaminated public drinking water, food, and soil across the United States.
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PFAS are ubiquitous—we are all exposed to them,” Chatzi said. “
We need to eliminate that exposure to allow our youth to reach their full potential in terms of bone development to help them avoid osteoporosis later in life. It’s important to regulate PFAS as a class because we are not just exposed to one chemical, we are exposed to thousands of chemicals”.
Bone mineral density increases during adolescence, peaks between the ages of 20 and 30, then slowly decreases throughout adulthood. Peak bone mineral density helps predict whether a person will get osteoporosis later in life, prompting the researchers to investigate how PFAS can affect young people.
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We want to make sure we’re not exposing ourselves to things that harm our bone development, because it has implications over the rest of our lives,” Beglarian said.
The researchers say stricter regulations are needed for PFAS, especially to protect high-risk communities such as Hispanics who also face increased exposures to other types of pollutants. While the burden of reducing PFAS should not fall to individuals, the researchers are planning outreach efforts to help people learn how to limit their personal exposure. Tips include avoiding nonstick pans and personal care products known to include PFAS.
Chatzi, Beglarian and their colleagues are also expanding their research to confirm the findings across the lifespan and in other communities throughout the U.S., with a continued focus on Hispanics. They also plan to study the biological mechanisms behind the effects of PFAS on bone health, including looking for biomarkers that could indicate bone health is at risk before osteoporosis sets in.
Source: Keck School of Medicine of USC