TAGS: Skin Care
Kao Corporation’s Skin Care Research Laboratory and Analytical Science Laboratory found that the stratum corneum endogenous ceramides profile shifts by daily treatment of atopic skin with a skin care lotion containing synthetic pseudo ceramide. These findings showed not only the importance of skin care, but also a new function of for atopic skin.
Daily Skin Care to Treat Atopic Dermatitis
Atopic dermatitis is characterized by immunological hypersensitivity to allergen substances, as well as clinical symptoms of severe skin inflammation and dryness. The Atopic Dermatitis Treatment Guidelines recommend daily skin care to reduce skin symptoms and maintain remission by normalization of stratum corneum functions.
The stratum corneum ceramide level is also known to be decreased in non-lesional sites of skin in atopic dermatitis patients, one of the causes of stratum corneum function decline seen in atopic skin. In addition, the stratum corneum ceramide profile of atopic skin shifts from that of healthy skin. However, little is known about the relationship between changes in stratum corneum ceramide profile and stratum corneum function in atopic dermatitis.
Thus, the influence of changes in stratum corneum functions on endogenous ceramide profile was investigated in atopic dermatitis patients.
Daily Treatment Promotes Healthy Skin
The study was performed with atopic dermatitis patients diagnosed by a dermatologist as not requiring medical treatment following provision of informed consent. The study volunteers treated their skin twice a day with a test lotion for four weeks. During that period, they did not use medical treatment drugs or other skin care products, except for the test lotion.
Stratum corneum samples were collected from the volunteers after four weeks of treatments with the test lotion. Synthetic pseudo-ceramide, endogenous ceramides, and stratum corneum water content were examined.
Interesting results were obtained in the study showing that daily treatment with a skin care lotion containing synthetic pseudo-ceramide changed the endogenous ceramide profile of individuals with atopic dermatitis to that of healthy skin as well as penetration of synthetic pseudo-ceramide into the stratum corneum.
Kao plans to use knowledge gained in this study, considered to be important for skin care in patients with atopic dermatitis, for future skin research investigations.
Source: Kao