TAGS: Skin Care
Amorepacific R&D Center and KAIST together develop an original technology that reverses the aging process in human dermal fibroblasts. The system’s biology research was conducted in collaboration with a research team led by Professor Cho Kwang-hyun of the department of bio and brain engineering at KAIST.
Core Factor Reverses Aging in Old Cells
As skin cells get older, their ability to divide becomes significantly weakened, slowing down the speed of regeneration and the overall functionality of skin tissue. The cells also lose the ability to produce collagen and elastic fibers which, in turn, slows down skin regeneration making the skin thinner, and thus creating wrinkles. In addition, a weak skin barrier causes frequent dryness, itchy skin, and other troubles.
In this industry-university research collaboration, Amorepacific R&D Center and Professor Cho’s team developed a signaling network model for aging skin cells. The joint team ran simulations to analyze the model and discovered a core factor that reverses aging in old cells and converts them into younger cells. Using this factor, the team managed to develop an original technology for reverse aging.
PDK1 Recovers Skin’s Ability to Regenerate
With the help of these findings, the joint team has found the potential to reverse the biological phenomenon of aging in skin cells that was previously considered irreversible. When the scientists regulated the activity of PDK1 (3-phosphoinositide–dependent protein kinase 1), the core factor that reverse aging, in the artificial model of aged skin, they found that PDK1 inhibition not only reverses the reduction in collagen synthesis, but also helps recover the skin’s ability to regenerate. It is expected that the joint team can leverage this reverse aging technology to not only predict and suppress the progress of age-related diseases, but also to prolong the healthy years of life.
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The joint research enabled us to build an aging signal network model and an artificial model for aged skin, with which we saw the potential to reverse the aging process in the skin. Amorepacific will continue to build on our studies on dermatology and bio sector to slow down or improve the progress of aging that was previously thought impossible. We will continue to put in our utmost efforts to safeguard the health of our customers worldwide,” Park Won-seok, director of Research & Innovation Center at Amorepacific R&D Center.
Based on the results of the studies, Amorepacific R&D Center is developing cosmetics that reduce wrinkles by extracting a core ingredient in Camellia japonica seed extract that controls aging in human skin.
Source: Amorepacific