Currently, 5-fluorouracil (5-FU) cream is indicated for the treatment of actinic keratoses (AKs). 5-FU cream is not currently indicated for the treatment of unblemished skin, that is, skin with no clinically apparent AKs or nonmelanoma skin cancer. During treatment of AKs with 5-FU cream, subclinical sun damage often will become clinically apparent. Actinically damaged cells grow and divide more r