TAGS: Skin Care
Shiseido has discovered for the first time ever that laminin-511, a key component of the epidermal basement membrane existing between the epidermis and dermis, plays an important role in maintaining epidermal stem cells, which are a vital factor for skin rejuvenation.
Active Ingredient Developed After 12 Years of Research
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| Stemlan-173 protects laminin-511 degradation and maintains epidermal stem cells |
At the same time, in understanding that laminin-511 degrades with UV exposure, Shiseido has after 12 years of ongoing research developed Stemlan-173, a new active ingredient effectively protecting the degradation of laminin-511, and confirmed that by inhibiting the degradation of laminin-511 through treatment with Stemlan-173, the epidermal basement membrane maintains good condition in research subjects aged zero to their 60s , suggesting that Stemlan-173 has a significant skin texture improving effect.
Furthermore, Shiseido also discovered that algae extract acts as an active ingredient to promote the production of laminin-511, which decreases with aging.
Going forward, Shiseido will apply these new findings to the development of skincare products as an effective technology that helps all sorts of consumers to rejuvenate their skin.
Laminin-511 & Epidermal Basement Membrane
Shiseido has conducted research with a focus on the basement membrane for 30 years, and identified that UV damage to the basement membrane induces the formation of wrinkles and dark spots.
Through further research, it was also discovered that epidermal stem cells decrease due to damage to the basement membrane. This time, in searching for a basement membrane component involving the decrease of epidermal stem cells, the research team discovered for the first time ever that laminin-511 prevents the decrease of and maintains epidermal stem cells.
Ingredient that Protects Degradation of Laminin-511
After pursuing further research on laminin-511, which plays an important role in maintaining epidermal stem cells, Shiseido confirmed the following two factors causing skin aging:
- Laminin-511 degrades with UV exposure
- Laminin-511 decreases with aging
Therefore, Shiseido searched for an ingredient that protects the degradation of laminin-511 among approx. 20,000 candidate ingredients expected to have a beneficial effect on skin, and after 12 years of ongoing research, succeeded in developing Stemlan-173, a new active ingredient that significantly protects the degradation of laminin-511 and maintains epidermal stem cells.
Moreover, the team also searched for an ingredient promoting the production of laminin-511 among approx. 180 naturally-derived extracts and determined the effectiveness of algae extract.
Stemlan-173’s Skin Improvement Effect
Shiseido confirmed that Stemlan-173 improves skin rejuvenation and overall skin condition by protecting the degradation of laminin-511 and the decrease of epidermal stem cells. It is known that epidermal stem cells decrease from the peak amount at birth with aging, whereas Stemlan-173 protects the decrease of and maintains epidermal stem cells. Looking ahead, Shiseido will apply Stemlan-173 to the production of new skincare products as it helps all sorts of consumers to rejuvenate their skin.
Source: Shiseido