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Mibelle Biochemistry Launches Upcycled Ingredient to Combat Inflammaging

Published on 2022-11-14. Edited By : SpecialChem

TAGS:  Sustainability / Natural Cosmetics    Skin Care    

Mibelle Biochemistry Launches Upcycled Ingredient to Combat InflammagingMibelle Biochemistry launches CALMandrin™, an efficient solution to combat inflammaging. The natural aging processes are accompanied by a chronic, low-grade background of inflammation called “inflammaging”. This term is composed of the two words inflammation and aging.

Improves Signs of Aging

CALMandrin™ is sustainably obtained by upcycling the peel paste from unique organic Chios mandarins. It is COSMOS-approved and NATRUE-approved.

CALMandrin™ is a sustainable solution for combatting inflammaging by notably improving the signs of aging, as well as soothing reddened and inflamed skin. In addition to its calming effect on irritated skin, it also markedly increases the firmness and density of the skin.

The ability of the human body to counteract inflammation reduces with age. Therefore, inflammation can no longer be completely eliminated, and low-grade chronic inflammation occurs, which contributes to the development of age-related conditions.

Furthermore, both intrinsic and extrinsic stressors promote the chronological aging process and lead to an accumulation of damage in all tissues of the body.

Related Read: Ingredients for Anti-aging Cosmetics

Proven Efficacy

In vitro

  • Reduction of inflammatory gene expression in keratinocytes
  • Reduction of inflammation reaction induced by inflammatory keratinocyte secretion
  • Reduction of protein carbonylation induced by inflammation in keratinocytes
  • Increase in procollagen I secretion in keratinocytes
  • Production of newly formed collagen in skin explants

In vivo

  • Reduction of skin redness
  • Improvement of skin elasticity
  • Improvement of skin firmness
  • Improvement of skin density


  • Calms irritated skin
  • Soothes inflamed and reddened skin
  • Promotes collagen production
  • Improves skin firmness and skin density

Explore Anti-aging Agents from Mibelle Biochemistry

Source: Mibelle Biochemistry

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