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The material selection platform
Cosmetics Ingredients
The material selection platform
Cosmetics Ingredients

TETRASODIUM GLUTAMATE DIACETATE

CAS Number 51981-21-6
Chem/IUPAC Name: Tetrasodium;(2S)-2-[bis(carboxylatomethyl)amino]pentanedioatee
EINECS/ELINCS No: 257-573-7
COSING REF No: 60281
TETRASODIUM GLUTAMATE DIACETATE
Tetrasodium Glutamate Diacetate is a 'chelating agent'. It usually appears as an odorless white powder that is soluble in water, and is used as a multi-purpose, clear, liquid chelating agent and preservative booster. It has a molecular weight of 351.13 and its molecular formula is C9H9NNa4O8.

What is TETRASODIUM GLUTAMATE DIACETATE used for?

Tetrasodium Glutamate Diacetate inactivates metallic ions (charged particles) in product formulations, hence acting as is a chelating agent. Free roaming iron and copper ions in formulations can lead to rapid oxidation. Using a chelating agent helps to slow this process, allowing for the creation of products with improved stability and appearance. This also improves the effectiveness of preservative ingredients, allowing us to use a lower percentage of these, for safer shelf-stable products. Tetrasodium Glutamate Diacetate is often found in sunscreen, facial cleanser, shampoo, makeup, lotion, cleansing wipes, bar soap, and other cleaning products.

Origin

Tetrasodium Glutamate Diacetate is an organic salt synthesized from glutamic acid (an amino acid abundant in nature).

What does TETRASODIUM GLUTAMATE DIACETATE do in a formulation?

  • Chelating

Safety profile

The safety of Tetrasodium Glutamate Diacetate was assessed by the Expert Panel for Cosmetic Ingredient Safety (formerly called the Cosmetic Ingredient Review Expert Panel) in 2021. The Expert Panel concluded that it was safe as used in the present practices of use and concentration in cosmetics and personal care products. The Expert Panel noted Tetrasodium Glutamate Diacetate is slowly absorbed through the gastrointestinal tract and skin absorption is likely to be even slower. The Expert Panel also noted the lack of carcinogenicity (cancer-causing potential) data and that it may contain a salt of nitrilotriacetic acid, a category 2B carcinogen according to the International Agency for Research on Cancer (IARC). However, the concern was mitigated by multiple genotoxicity studies (both in vitro and in vivo), which did not indicate adverse genetic activity at the low concentrations of this ingredient in leave-on products.

TETRASODIUM GLUTAMATE DIACETATE Alternatives

Technical profile

Property Values
Boiling Point 105-110°C
Specific Gravity 1.15-1.45
pH 11-12 (in 1% water)
Solubility Completely miscible in water
Slightly soluble in methanol/ethanol
Viscosity 75-275 mPa.s @ 25°C
5

Commercial Selection : Grades containing solely TETRASODIUM GLUTAMATE DIACETATE

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