The material selection platform
Cosmetics Ingredients
The material selection platform
Cosmetics Ingredients


CAS Number 64-02-8
Chem/IUPAC Name: Tetrasodium ethylenediaminetetraacetate
EINECS/ELINCS No: 200-573-9
COSING REF No: 38569
Tetrasodium EDTA (Ethylene Diamine Tetraacetic Acid) is a chelating agent commonly utilized in cosmetics and personal care products. Functioning as a stabilizer, it enhances product quality by preventing deterioration and discoloration caused by trace metal ions. In skincare, Tetrasodium EDTA promotes the effectiveness of other ingredients by preventing the interference of metal ions present in water. This versatile compound is particularly beneficial in formulations like cleansers, shampoos, and skincare products, contributing to their longevity and performance. While generally regarded as safe for topical use, its inclusion is often a strategic choice to maintain the stability and efficacy of cosmetic formulations. The chemical formula of Tetrasodium EDTA is C10H12N2Na4O8.

What is TETRASODIUM EDTA used for?

Tetrasodium EDTA is quite a beneficial ingredient for personal care and cosmetic products.
  • Skin care: It helps maintain product stability, preventing deterioration caused by metal ions. It supports the efficacy of other active ingredients by neutralizing metal ions present in water, enhancing the overall performance of cleansers, toners, and creams
  • Hair care: It prevents mineral buildup, ensuring shampoos and conditioners remain effective. It promotes product longevity, leaving hair formulations with enhanced stability and performance
  • Decorative makeup: As a chelating agent in cosmetics, Tetrasodium EDTA preserves product quality by preventing discoloration and degradation. It supports the stability of makeup formulations, contributing to their longevity and maintaining optimal performance on the skin


Tetrasodium EDTA is synthesized through a chemical reaction involving ethylenediamine, formaldehyde, sodium cyanide, and sodium hydroxide. The resulting ingredient appears as a white solid that is then purified for use in cosmetics.

What does TETRASODIUM EDTA do in a formulation?

  • Chelating

Safety profile

Tetrasodium EDTA is a safe ingredient for cosmetic and personal care products. However, patch testing is necessary and individuals with specific skin sensitivities should consult a healthcare professional if needed. Additionally, concerns have been raised about the environmental impact of Tetrasodium EDTA since it contributes to metal pollution. Manufacturers and consumers are encouraged to be mindful of environmental considerations and explore alternative ingredients with lower environmental impact when possible. Further, Tetrasodium EDTA can be considered vegan if not derived from animal sources. It is also halal-certified.

Technical profile

Property Values
Boiling Point 614°C
Melting Point >300°C
Solubility Highly soluble in water

Commercial Selection : Grades containing solely TETRASODIUM EDTA

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