The Universal Selection Source: Cosmetics Ingredients

Patent

SMALL MOLECULE INHIBITORS OF TRPA1


Application Date:
Apr 12, 2017
EPO Patent:
EP 3153161 A1
Abstract:

The present invention relates to the use of compounds which are capable of attenuating skin irritation when they are applied to the skin. Skin irritation can be caused, enter alia, by ingredients of cosmetic or phar...

Inventors:
KROHN, Michael
SOMBROEK, Dirk
International Classification:
A61K 31/192 20060101AFI20170301BHEP

Claims

What is claimed is:

Compound V.2 having the following general formula: or a salt or solvate thereof wherein: R1 is -(C1-C4)alkyl, -(C2-C4)alkenyl, -(C2-C4)alkynyl, or (C1-C4)alkoxy, each of which is unsubstituted or substituted with 1 or 2 independently selected R5 groups;R2 is -H or -CH3;R2' is -H or -CH3;each R3 is independently: (a) -OT3, or -OC(=O)T3; or(b) -C(=O)T3,...

Description

SUBJECT OF THE INVENTION

The present invention relates to the use of compounds which are capable of attenuating skin irritation when they are applied to the skin. Skin irritation can be caused, inter alia, by ingredients of cosmetic or pharmaceutical compositions and/or environmental irritants. In particular, the present invention relates to compounds having the...

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