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Shiseido’s New Technology Reveals the Root Cause of Wrinkle Formation

Published on 2021-02-02. Edited By : SpecialChem

TAGS:  Skin Care    

Shiseido_Discover_WrinklesShiseido has independently developed cutting-edge technology for imaging skin elasticity in three dimensions and successfully observed the root cause of wrinkles, including invisible wrinkles.

Skin Elasticity Deteriorates with Age


Using this technology, the researchers analyzed the mechano-physical properties of skin for consumers in various age groups, from young to senior, and found that the “balance of elasticity between the stratum corneum and the dermis” deteriorates with age, concluding that such phenomenon is the root cause of wrinkle formation.

The mechanical properties of the skin have generally been evaluated considering skin as “one object”, for instance, how skin bounces against the forces of pressure, etc. However, as skin consists of multiple layers with different properties, a technique was required that can evaluate properties by layer to accurately understand mechanical properties of the skin.

The researchers utilized an ultrasound technique and developed new technology to analyze depth-specific elastic properties in the skin (repulsive force when pressed), previously impossible using the conventional method. With this most advanced ultra-high resolution and ultrasonic technology, it has become possible to evaluate a skin region with a thickness of one micron (1/1000 of 1 mm) and accurately analyze elastic properties by layer, even in a thin layer such as the stratum corneum, measuring only a few tens of microns.

Elasticity Gap Leads to Deeper Wrinkles


Using the above evaluation technology, the researchers analyzed the mechanical properties of skin in 130 Japanese women aged 20s to 60s and evaluated the elastic properties of each skin layer. As a result, the researchers found that the stratum corneum became harder with age whereas the dermis became softer, and the more the elasticity gap between the stratum corneum and the dermis expands, the deeper the wrinkles become.

In terms of young skin with no visible wrinkles, those who have a larger elasticity gap between the stratum corneum and the dermis are more likely to form wrinkles when the skin is deformed, such as during facial expressions. This result suggests that the balance in elastic properties between the stratum corneum and the dermis is closely related to the state of wrinkles at all stages.

New Technology Improves Wrinkle-pronenesss


The company asked female volunteers in their 40s to apply a cream formulation containing simple form of retinol as well as moisturizing and softening agents repeatedly for four weeks, and analyzed the mechanical properties of the skin before and after the application by the technique developed and described above.

As a result, it was revealed that the elastic properties were resolved no matter whether wrinkles are visible or invisible. At the same time, it was found that not only visible wrinkles were improved, but temporal wrinkles that appear during facial movements (facial expressions) were also significantly reduced even in skin at pre-wrinkle stage. Based on these results, the researchers confirmed that a skin care approach combining caring both on the outside and within can improve “wrinkle-proneness” that develops within the skin even before wrinkles appear.

Shiseido has always responded to consumers’ needs through various research and innovation, such as developing active ingredient “simple form of retinol” that achieved not only high efficacy but also safety, and introducing it for wrinkle improvement which has been well-received by the market. The results of this study are important discoveries approaching the root cause of wrinkles, and by monitoring not only deep wrinkles but also pre-wrinkles that are outwardly invisible, it is expected to lead to a new approach to anti-aging skin care.

Shiseido will utilize the findings of our cutting-edge research and continue to carry out innovative studies to solve skin concerns for customers around the world.


Source: Shiseido
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