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Endocrine Disruptors Used in Cosmetics Have Negative Impact on Fertilization: Study

Published on 2014-05-13. Author : SpecialChem

BONN -- A plethora of endocrine-disrupting chemicals interfere with human sperm function in a way that may have a negative impact on fertilization. These are the findings of a German - Danish team of researchers from the Center of Advanced European Studies and Research in Bonn, Germany, and the University Department of Growth and Reproduction, Rigshospitalet, Copenhagen, Denmark. The work, which is published in EMBO reports, suggests that endocrine disruptors may contribute to widespread fertility problems in the Western world in a way that hitherto has not been recognized.

Endocrine disruptors are present in food, textiles, drugs, household, and personal-care products such as plastic bottles, toys, and cosmetics. Proving the deleterious effects of endocrine disruptors on human beings has been difficult due to a lack of suitable experimental systems.

The European Commission is currently reviewing its policy on endocrine-disrupting chemicals. Last year, their plans caused a debate between endocrinologists and a group of toxicologists over how to regulate these chemicals. "Our study provides scientific evidence to assist forming international rules and practices," said the leader of the study, Timo Strünker, from the Center of Advanced European Studies and Research in Bonn, Germany.

"For the first time, we have shown a direct link between exposure to endocrine disrupting chemicals from industrial products and adverse effects on human sperm function,’’ said Niels E. Skakkebaek, professor and leader of the Danish team.

Hundreds to thousands of chemicals can be rapidly tested for their potential to interfere with human sperm function using the bioassay developed by the researchers. In this initial study, about one hundred chemicals were tested. Around one third, including ultraviolet (UV) filters like 4-methylbenzylidene camphor (4-MBC) used in some sunscreens, the anti-bacterial agent Triclosan used in toothpaste, and di-n-butylphthalate (DnBP), showed adverse actions.

The scientists looked at the impact of these chemicals on the CatSper ion channel, a calcium channel controlling sperm motility. They showed that endocrine disruptors – applied at concentrations measured in body fluids – directly open CatSper and, thereby, increase calcium levels in sperm, change their swimming behavior, and trigger the release of digestive enzymes that help sperm to break through the egg coat. Moreover, endocrine disruptors render sperm less sensitive for progesterone and prostaglandins – two important hormones released by cells surrounding the egg. Finally, the authors noted that in low-dose mixtures, the chemicals cooperate to elevate calcium levels in sperm.

Altogether, the study indicates that endocrine disruptors might disturb the precisely coordinated sequence of events underlying fertilization in several ways: the chemicals might evoke changes in swimming behavior at the wrong time and wrong place, hinder navigation of sperm towards the egg, and hamper penetration into the protective egg coat.

About EMBO

EMBO is an organization of almost 1600 leading researchers that promotes excellence in the life sciences. The major goals of the organization are to support talented researchers at all stages of their careers, stimulate the exchange of scientific information, and help build a European research environment where scientists can achieve their best work.

EMBO helps young scientists to advance their research, promote their international reputations and ensure their mobility. Courses, workshops, conferences and scientific journals disseminate the latest research and offer training in techniques to maintain high standards of excellence in research practice. EMBO helps to shape science and research policy by seeking input and feedback from our community and by following closely the trends in science in Europe.

About caesar

Research center caesar (Center of Advanced European Study and Research) was founded in 1995 as part of the compensatory actions under the Berlin/Bonn law, which were intended to support structural change in the region of the former capital. The independent foundation operates under private law with foundation capital from the governments of Germany and the State of North Rhine-Westphalia. caesar is closely associated with the Max Planck Society (MPG). The President of the Max Planck Society chairs the Board of Trustees. The caesar-directors are scientific members of the Max Planck Society. The appointment of the directors, the evaluations and the safeguarding of scientific excellence are realized according to the criteria of the Max Planck Society.

Source: caesar


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